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Name of Collaboratory :

 

Comparative Mouse Genomics Centers Consortium (CMGCC)

 
 

URL :

  http://www.niehs.nih.gov/cmgcc/home.htm  
 

Collaboratory Status :

 
Completed   Start Date : 2001 End Date : Info Last Updated : Thu, Dec 9 2010 12:01pm PST
 
 

Primary Collaboratory Function :

  Distributed Research Center  
 

Secondary Collaboratory Functions :

  Community Data Systems  
 

Domain(s) :

  EARTH, ATMOSPHERIC, AND OCEAN SCIENCES >Other Environmental Sciences >Environmental Science
BIOLOGICAL/AGRICULTURAL SCIENCES >Biological Sciences >Cell Biology, BIOLOGICAL/AGRICULTURAL SCIENCES >Biological Sciences >Molecular Biology, BIOLOGICAL/AGRICUL
 
 

Brief Description of the Collaboratory :

 

The Comparative Mouse Genomics Centers Consortium (CMGCC) was initiated by the EGP to develop transgenic and knockout mouse models based on human DNA sequence variants in environmentally responsive genes. These mouse models are useful tools to improve our understanding of the biological significance and functional relevance of these polymorphisms in human disease, particularly when validated with controlled exposures and environmental challenges. This program has resulted in the discovery of unique variants in environmentally responsive genes, the development of a number of resources, and capacity building in the environmental epidemiology communities in order to incorporate gene-environment hypotheses and tools into human population-based studies on a number of environmentally relevant diseases. The models developed by the Consortium are being made available to the scientific community through an arrangement with the National Center for Research Resources (NCRR) for distribution by their Mutant Mouse Regional Repositories. This Consortium requires extensive collaboration and multidisciplinary research in molecular biology, biochemistry, structural biology, as well as expertise in mouse genetics and pathology, to achieve the following goals:

Identify relevant and feasible mouse models for development by the Consortium;
To identify mouse models that are relevant to human environmental health; and
To validate developed mouse models that are relevant to human environmentally induced disease.

 
 

Access to Instruments :

   
 

Access to Information Resources :

  The models developed by the Consortium are being made available to the scientific community through an arrangement with the National Center for Research Resources (NCRR) for distribution by their Mutant Mouse Regional Repositories.  
 

Access to People as Resources :

   
 

Funding Agency or Sponsor :

 
United States Department of Health and Human Services
National Institutes of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
 
 
 

Notes on Funding Agencies/Sponsors:

 
 
 
Organizations with Funded Participants:
 
Organization name:
Approx # of participants:
Description of organization's role(s):
Buck Institute for Research on Aging
Models for DNA Repair & Cell Cycle Control Variants
University of Chicago (UChicago)
   NORC
      Data Research and Development Center
Harvard University
   Harvard Medical School
Mouse Models for DNA Repair Defects
University of Cincinnati (UC)
Comparative Mouse Genomics Center Consortium
University of Texas M. D. Anderson Cancer Center
Mouse Model of Cell Cycle Deregulation in Cancer
University of Washington
Seattle Comparative Mouse Genomics Center
 
TOTAL PARTICIPANTS:
 

Notes on Participants/Organizations:

   
     
 
 

Communications Technology Used :

   
 

Technical Capabilities :

   
  Key Articles :    
 

Project-reported performance data :

  The Comparative Mouse Genomics Centers Consortium is credited with the construction of over 30 mouse models available to the scientific community through the National Center for Research Resources (NRCC) Mutant Mouse Regional Repositories.  
 
         
    
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