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Name of Collaboratory :

 

Cancer Biomedical Informatics Grid (caBIG)

 
 

URL :

  http://cabig.cancer.gov/  
 

Collaboratory Status :

 
Operational   Start Date : 2004 End Date : Info Last Updated : Mon, Dec 6 2010 3:00am PST
 
 

Primary Collaboratory Function :

  Virtual Community of Practice  
 

Secondary Collaboratory Functions :

  Community Data Systems, Community Infrastructure Development  
 

Domain(s) :

  BIOLOGICAL/AGRICULTURAL SCIENCES >Biological Sciences >Biomedical Sciences, BIOLOGICAL/AGRICULTURAL SCIENCES >Biological Sciences >Pathology, Human and Animal
Cancer research
 
 

Brief Description of the Collaboratory :

 

The mission of caBIG® is to develop a collaborative information network that accelerates the discovery of new approaches for the detection, diagnosis, treatment, and prevention of cancer. caBIG® is sponsored by the National Cancer Institute (NCI) and its activities are supervised by the National Cancer Institute Center for Bioinformatics and Information Technology (NCI-CBIIT). The initiative operates through an open development community. Anyone can participate in caBIG® and there is no cost to join. The community includes over 50 Cancer Centers, other NCI-supported research endeavors, and a variety of federal, academic, not-for profit and industry organizations.

The goals of caBIG® are to:

* Connect scientists and practitioners through a shareable and interoperable infrastructure
* Develop standard rules and a common language to more easily share information
* Build or adapt tools for collecting, analyzing, integrating, and disseminating information associated with cancer research and care.

Since its start, caBIG® has committed to the following principles:

* Federated: caBIG® software and resources are widely distributed, interlinked, and available to everyone in the cancer research community, but institutions maintain local control over their own resources and data.
* Open-development: caBIG® tools and infrastructure are being developed through an open, participatory process. caBIG® leverages existing resources whenever possible, rather than building new tools in every case.
* Open-access: caBIG® resources are freely obtainable by the cancer community to ensure broad data-sharing and collaboration.
* Open-source: The caBIG® source code is available to view, alter, and redistribute.

caBIG® forms the information infrastructure of The Cancer Genome Atlas, an integrated database of molecular and clinical data. caBIG® provides the connectivity, data standards, and tools required to collect, organize, share, and analyze the diverse research data from multiple laboratories and among different institutions that populates this database. The TCGA web portal provides researchers and clinicians the ability
to easily perform complex queries on this database, giving them unprecedented opportunities to discover and develop a new generation of targeted diagnostics, therapies, and preventive interventions for cancer.

 
 

Access to Instruments :

   
 

Access to Information Resources :

  * LISTSERVS - Workspaces and project teams maintain LISTSERVS to announce upcoming events, meetings and new products and information. Visit the caBIG® Announce Listserv to sign up for general announcements.
* Knowledge Centers – For questions about a specific caBIG® tool or domain, PEOPLE browse and post to bulletin boards managed by the caBIG® Knowledge Centers. There is also a General Forum for questions that do not fit into a Knowledge Center or that are cross-cutting in nature.
* Annual Meetings The caBIG® community gathers annually to celebrate successes, address caBIG®-wide and cross-workspace topics, and demonstrate emerging and available products, including software tools, databases, prototypes, white papers, and developmental models. Special sessions are also offered for those new to caBIG®. There is no charge for the meeting.
 
 

Access to People as Resources :

  * caBIG® Workspaces: Many caBIG® activities take place within workspaces, virtual teams of funded and volunteer community members that develop technologies, white papers, guidance, and other deliverables, and help shape the workspace's strategic direction. Visit the caBIG® Workspaces. Each workspace holds regular teleconference calls and periodic face-to-face meetings, open to anyone with interest.
* Annual Meetings The caBIG® community gathers annually to celebrate successes, address caBIG®-wide and cross-workspace topics, and demonstrate emerging and available products, including software tools, databases, prototypes, white papers, and developmental models. Special sessions are also offered for those new to caBIG®. There is no charge for the meeting.
* The NCI-CBIIT Application Support Group is dedicated to helping users use caBIG® tools and resources to maximum benefit.
* The Enterprise Support Network (ESN), composed of Knowledge Centers and Support Service Providers, supplies expertise and
implementation help to ease and expedite the integration of caBIG® technology.
 
 

Funding Agency or Sponsor :

 
United States Department of Health and Human Services
National Institutes of Health (NIH)
National Cancer Institute (NCI)
 
 
 

Notes on Funding Agencies/Sponsors:

 
 
 
Organizations with Funded Participants:
 
Organization name:
Approx # of participants:
Description of organization's role(s):
United States Department of Health and Human Services
   National Institutes of Health (NIH)
      National Cancer Institute (NCI)
         Center for Biomedical Informatics (NCICB)
 
Organizations Otherwise Associated:
 
Organization name:
Approx # of participants:
Description of organization's role(s):
Abbott Laboratories
Astra Zeneca
Participating organization
Cardiff University
Participating organization
Centocor
Participating organization
Centre for Development of Advanced Computing
Participating organization
Curie Institute
Participating organization
Drexel University
Participating organization
Dublin Institute of Technology
Participating organization
Eli Lilly and Company
Participating organization
Erasmus Medical Center
Participating organization
United States Department of Health and Human Services
   Food and Drug Administration (FDA)
Participating organization
Friedrich Miescher Institute for Biomedical Research
Participating organization
Genentech
Participating organization
Genesis Research and Development Corporation Limited
Participating organization
Glaxo Smith Kline
Participating organization
Hiroshima University
Participating organization
Imperial College London
Participating organization
Inserm
Participating organization
Medarex
Participating organization
Moscow State University
Participating organization
National University of Singapore
Participating organization
National Yang-Ming University
Participating organization
Ohio State University
Ontario Cancer Institute
Participating organization
Roche Holding AG
Participating organization
Taiho Pharmaceutical Co., Ltd.
Participating organization
Takeda Pharmaceutical Company Limited
Participating organization
Tulane University
Participating organization
University of Alabama at Birmingham
University of Crete
Participating organization
University of Edinburgh
Participating organization
University of Pune
Participating organization
University of Queensland, Australia
Participating organization
Washington University in St. Louis
 
TOTAL PARTICIPANTS:
 

Notes on Participants/Organizations:
The caBIG® community includes over 50 Cancer Centers, numerous other NCI-supported research endeavors, 30 federal, academic, not-for profit and industry organizations and more than 1500 individuals. Altogether there are more than 2300 individuals from 740+ institutions

Cancer Centers

NCI-designated Cancer Centers

caBIG® was conceived, designed, and developed in partnership with the NCI-designated Cancer Centers. Currently, more than 56 NCI-designated Cancer Centers across the nation are working to connect their research and clinical care capabilities into a caBIG®-enabled information network. Furthermore, teams from the cancer centers and their communities are involved in the development and testing of tools and other resources that are part of the ongoing design of caBIG®.

NCI Community Cancer Center Program (NCCCP)

Through the NCI Community Cancer Centers Program, 16 Community Cancer Centers—together touching 20 million lives—are part of the caBIG® network.
National Cancer Institute

NCI SPOREs (Specialized Programs Of Research Excellence)

caBIG® technology is enabling research projects across multiple SPOREs, which encourage research into particular cancer types. Biospecimen management is especially important to this audience, and caGrid and caTissue are being used to share information about biospecimens among 11 Prostate SPORE member organizations.

NCI Cooperative Groups

caBIG® tools and infrastructure have also been shared with the NCI Cooperative Groups, which are responsible for more than 1,700 trial sites, 30,000 new accruals per year, and 100,000 patients in active follow-up.

NCI Advanced Technologies Initiatives

caBIG® has become the underlying information infrastructure for a number of NCI advanced technologies initiatives, including the Alliance for Nanotechnology in Cancer, the Clinical Proteomic Technologies for Cancer Initiative, The Cancer Genome Atlas, and NCI's clinical trials activities.
Health Information Technology Initiatives

caBIG® is also used as an electronic "connector" to link disparate sectors of the healthcare system. Specific projects include the Family Health History Tool, the Nationwide Health Information Network, and the Oncology Electronic Health Record.
Individuals

Cancer biologists, clinical researchers, bioinformaticians, biobank managers, oncologists, radiologists, software developers, patient advocates, and others in the cancer community participate in caBIG® in multiple ways. This participation includes: accessing data using caBIG® tools, infrastructure, and resources; as well as participating in workspaces, ongoing caBIG® meetings, and other activities.

Industry and Other Partners

Commercial organizations—such as IT companies, large-scale software vendors, pharmaceutical and biotech companies, nonprofit organizations, community care facilities, and academic institutions—engage in caBIG® in a variety of ways, from participation in open meetings to deep involvement with specific caBIG® workspace activities.

There are caBIG participants from Argentina (caBIG® applications and technologies are being reviewed as part of the U.S.-Latin America Cancer Research Network), Australia (BioGrid Australia is actively collaborating with the caGrid development team to expand their grid capabilities), Brazil (caBIG® applications and technologies are being reviewed as part of the U.S.-Latin America Cancer Research Network), Chile (caBIG® applications and technologies are being reviewed as part of the U.S.-Latin America Cancer Research Network), China (Duke University Comprehensive Cancer Center and Beijing Cancer Hospital are using caBIG® capabilities to conduct the first clinical trials in China in which all patients will be registered electronically), Germany (The University of Cologne is implementing the caBIG® Adverse Event Reporting System to help manage clinical trials events), India (The All India Institute of Medical Sciences, the Center for Development of Advanced Computing, and the Tata Memorial Hospital of Mumbai are incorporating grid computing to manage clinical trials), Jordan (caBIG® applications and technology will be deployed throughout the King Hussein Institute for Cancer and Biotechnology as part of the NCI's memorandum of understanding with the King Abdullah II Fund for Development), Mexico (caBIG® applications and technologies are being reviewed as part of the U.S.-Latin America Cancer Research Network), Netherlands (The Center for Translational Molecular Medicine—a consortium of five academic institutions and eight industry organizations across the Netherlands—is deploying several caBIG® applications in support of translational research), New Zealand (The University of Otago in New Zealand has installed the caBIG® microarray data management system, caArray, and is connected to caGrid), Pakistan (Clinical researchers at the Aga Khan University in Pakistan have installed the complete caBIG® Clinical Trials Suite and are preparing to collect data from multiple clinical trials), United Kingdom (The NCI collaboration with the National Cancer Research Institute in the United Kingdom has focused on the use of caGrid technology to connect researchers and enable exchange of research data), Uruguay (caBIG® applications and technologies are being reviewed as part of the U.S.-Latin America Cancer Research Network).

   
     
 
 

Communications Technology Used :

  Many caBIG® activities take place within workspaces, virtual teams that develop technologies, white papers, guidance and other deliverables in specific areas of interest. The workspaces serve as self-sustaining communities of partners in which tools and ideas are continually being developed, shared, and improved. Workspace participants provide data, subject matter expertise, and solutions; create and evaluate standards; and help shape the workspace's strategic direction - ultimately identifying, prioritizing, and fulfilling the needs of the specific area of focus of the workspace. Participants in caBIG® fulfill one or more roles: developing or modifying interoperable tools (e.g., software, infrastructure); adopting tools and providing feedback to the workspace; mentoring others in data model and tool development, software development, documentation or training activities; and contributing to white papers in strategic, policy or technology areas.  
 

Technical Capabilities :

   
  Key Articles :    
 

Project-reported performance data :

  • 2,300+ people participating in the program from more than 700 institutions
•1,050 attendees at the 2009 caBIG® Annual Meeting, more than 600 of whom were there for the first time
•70+ organizations connected to caGrid, the interoperable IT network designed to facilitate data sharing, including 56 NCI-designated Cancer Centers and members of the NCI Community Cancer Center Program (NCCCP)
• 30 peer-reviewed scientific publications in which caBIG® tools and technology enabled the research or were the main focus of the paper
• 1.19 million biospecimens available through caGrid
• 3.71+ million medical images stored in the National Biomedical Imaging Archive (NBIA)
• 25,000+ microarray experiments available for research use on caGrid
• 15 licensed Support Service Providers to sustain the biomedical community as they deploy caBIG® tools and technology
• 15 countries using or evaluating caBIG® tools and technology to facilitate collaborative biomedical research, in cancer and beyond
 
 
         
    
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