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Name of Collaboratory :

 

Cancer Genome Atlas (TCGA)

 
 

URL :

  http://cancergenome.nih.gov/  
 

Collaboratory Status :

 
Operational   Start Date : 2006 End Date : Info Last Updated : Sat, Dec 4 2010 1:01am PST
 
 

Primary Collaboratory Function :

  Distributed Research Center  
 

Secondary Collaboratory Functions :

  Community Data Systems  
 

Domain(s) :

  BIOLOGICAL/AGRICULTURAL SCIENCES >Biological Sciences >Biomedical Sciences, BIOLOGICAL/AGRICULTURAL SCIENCES >Biological Sciences >Molecular Biology  
 

Brief Description of the Collaboratory :

 

The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate our understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing. TCGA is a joint effort of the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), two of the 27 Institutes and Centers of the National Institutes of Health, U.S. Department of Health and Human Services.

The Cancer Genome Atlas (TCGA) is coordinated by a project team comprised of individuals from both the National Cancer Institute and the National Human Genome Research Institute and advised by an External Scientific Committee whose membership includes patient advocates, senior scientists and clinicians with relevant expertise in cancer, genomics and ethics.

There are five different components to the collaboratory:

1. Biospecimen Core Resource – Tissue samples are carefully cataloged, processed, checked for quality and stored, complete with important medical information about the patient. BCR centralized laboratories review and process blood and tissue samples and their associated data using optimized standard operating procedures for the entire TCGA Research Network.

2. Genome Characterization Centers (GCCs) – Genome Characterization Centers (GCCs) are responsible for characterizing all of the genomic changes found in the tumors studied as part of the TCGA program. The GCCs will use multiple platforms to provide data to the cancer research community on changes in miRNA and gene expression, single nucleotide polymorphisms and copy number changes. The GCCs will also be working to validate specific regions of interest through targeted sequencing. The genomic changes that are identified will be further studied by the Genome Sequencing Centers.

3. Genome Sequencing Centers (GSCs) – Genome Sequencing Centers (GSCs) perform large-scale DNA sequencing using the latest sequencing technologies. Supported by the National Human Genome Research Institute (NHGRI) large-scale sequencing program, the GSCs generate the enormous volume of data required by TCGA, while continually improving existing technologies and methods to expand the frontier of what can be achieved in cancer genome sequencing.

4. Data Coordinating Center (DCC) – The information that is generated by TCGA is centrally managed at the DCC and entered into public databases as it becomes available. Centralization of data facilitates data transfer between the network and the research community and makes data analysis more efficient.

5. Genome Data Analysis Centers (GDACs) – Immense amounts of data from array and second-generation sequencing technologies must be integrated across thousands of samples. These centers provide novel informatics tools to the entire research community to facilitate broader use of TCGA data.

 
 

Access to Instruments :

   
 

Access to Information Resources :

  The comprehensive data that have been generated by TCGA’s network approach are freely available and widely used by to the cancer community through the TCGA Data Portal.

The Cancer Genome Atlas (TCGA) Human Subjects Protection and Data Access Policies govern the access to TCGA data, use of tissues and related clinical data. These were collectively developed by the National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI).

TCGA Data Use Policy and Publication Guidelines promote the responsible use of TCGA data sets. All investigators, and their institutions, seeking access and use of TCGA data must acknowledge their agreement with TCGA policies and procedures, which are described in the TCGA Data Portal Data Use Certification.
 
 

Access to People as Resources :

   
 

Funding Agency or Sponsor :

 
United States Department of Health and Human Services
National Institutes of Health (NIH)
National Human Genome Research Institute (NHGRI)
National Cancer Institute (NCI)
 
 
 

Notes on Funding Agencies/Sponsors:

 
 
 
Organizations with Funded Participants:
 
Organization name:
Approx # of participants:
Description of organization's role(s):
Baylor College of Medicine
Genome Sequencing Center (Human Genome Sequencing Center)
Broad Institute
Genome Sequencing Center (Broad Institute Sequencing Platform) Genome Data Analysis Center
Washington University in St. Louis
   Washington University School of Medicine
Genome Sequencing Center (Washington University Genome Sequencing Center)
 
Organizations Otherwise Associated:
 
Organization name:
Approx # of participants:
Description of organization's role(s):
Baylor College of Medicine
Genome Characterization Center (Targeted Sequencing Center)
Brigham and Womens Hospital
Genome Characterization Center (Copy Number Alteration (Single Nucleotide Polymorphism Characterization))
British Columbia Cancer Agency (BC Cancer Agency)
Genome Characterization Center (miRNA Analysis)
Broad Institute
Genome Characterization Center (Copy Number Alteration (Single Nucleotide Polymorphism Characterization))
Harvard University
   Harvard Medical School
Genome Characterization Center (Copy Number Alteration (Single Nucleotide Polymorphism Characterization))
Institute for Systems Biology
Genome Data Analysis Center
International Genomics Consortium
Biospecimen Core Resources
Johns Hopkins University
Genome Characterization Center (Epigenomics)
Lawrence Berkeley National Laboratory (LBNL)
Genome Data Analysis Center
Memorial Sloan-Kettering Cancer Center
Genome Data Analysis Center
Nationwide Childrens Hospital
Biospecimen Core Resources
SRA International
Data Coordinating Center Management
University of California, Santa Cruz (UC Santa Cruz)
Genome Data Analysis Center
University of North Carolina
   University of North Carolina at Chapel Hill
Genome Characterization Center (Gene (mRNA) Expression) Genome Data Analysis Center
University of Southern California (USC)
Genome Characterization Center (Epigenomics)
University of Texas M. D. Anderson Cancer Center
Genome Data Analysis Center
 
TOTAL PARTICIPANTS:
 

Notes on Participants/Organizations:

   
     
 
 

Communications Technology Used :

   
 

Technical Capabilities :

   
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Project-reported performance data :

   
 
         
    
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