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Name of Collaboratory :

 

Breast and Prostate Cancer Cohort Consortium (BPC3)

 
 

URL :

  http://epi.grants.cancer.gov/BPC3/  
 

Collaboratory Status :

 
Operational   Start Date : 2003 End Date : 2011 Info Last Updated : Sat, Dec 4 2010 1:01am PST
 
 

Primary Collaboratory Function :

  Distributed Research Center  
 

Secondary Collaboratory Functions :

  Community Data Systems  
 

Domain(s) :

  BIOLOGICAL/AGRICULTURAL SCIENCES >Biological Sciences >Biomedical Sciences, BIOLOGICAL/AGRICULTURAL SCIENCES >Biological Sciences >Pathology, Human and Animal  
 

Brief Description of the Collaboratory :

 

Through the Breast and Prostate Cancer and Hormone-Related Gene Variant Study, the Breast and Prostate Cancer Cohort Consortium (BPC3) investigators pool data and biospecimens from 10 large prospective cohorts to conduct research on gene-environment interactions in cancer etiology.

The Consortium collaborates with three genomic facilities, epidemiologists, population geneticists, and biostatisticians from multiple institutions to study hormone-related gene variants and environmental factors in breast and prostate cancers.

The BPC3 has created an organizational structure to accelerate research, reported in meeting abstracts and journals. Among its findings, the BPC3 reported that ER-negative breast cancer is related to variants in the steroid metabolism gene HSD17B1. As genotyping data are developed, BPC3 provides resources for investigators, for example, sequencing data to select tag SNPs for 59 genes in sex steroid hormone and growth factor, and information on primers and probes.

In the fall of 2007, BPC3 received an additional four years of funding to test for certain single nucleotide polymorphisms (SNPs) that have been identified in genome-wide association studies (GWAS) as being associated with estrogen receptor negative breast and aggressive forms of prostate cancer, characterized by a high histologic grade (Gleason score 8+).

 
 

Access to Instruments :

   
 

Access to Information Resources :

  All of the sequencing and genotyping data generated in BPC3 are publicly available at the USC/Norris Comprehensive Cancer Center web site.  
 

Access to People as Resources :

  To achieve the goals of the consortium, several working groups have been created that coordinate the efforts within and across the participating cohorts and scientific disciplines. These structures are:

* Steering Committee: The Steering Committee includes the four principal investigators for the cooperative agreements that fund participation of the cohorts in the BCP3 Study, the principal investigators of the cohorts themselves (which are funded independent of this study), and NCI Program staff as Ex Officio members. The Steering Committee coordinates the activities of the research components, decides on a timeline for specific subcomponents of the study (e.g., the order in which groups of genes are genotyped), coordinates pooling of data, and distributes parts of the pooled data analyses to BCP3 Study members.
* Secretariat: Drs. David Hunter and Elio Riboli were elected co-chairs of the Steering Committee and serve as the Secretariat responsible for coordinating meetings, conference calls, and communications with NCI.
* Shared resources:
o Population Genetics Working Group
o Haplotype Determination Laboratories
o Genotyping Working Group
o Statistics Working Group
o Data Pooling Working Group
o Publications Working Group
o Community Web Site Working Group
 
 

Funding Agency or Sponsor :

 
United States Department of Health and Human Services
National Institutes of Health (NIH)
National Cancer Institute (NCI)
 
 
 

Notes on Funding Agencies/Sponsors:
Four of the participating cohorts are funded through the NCI's Epidemiology and Genetics Research Program (EGRP), Division of Cancer Control and Population Sciences (DCCPS). Two of the cohorts are funded by NCI's intramural research program, the Division of Cancer Epidemiology and Genetics (DCEG).

 
 
 
Organizations with Funded Participants:
 
Organization name:
Approx # of participants:
Description of organization's role(s):
American Cancer Society (ACS)
Cohort
Harvard University
   Harvard School of Public Health
Cohort
Imperial College London
Cohort
United States Department of Health and Human Services
   National Institutes of Health (NIH)
      National Cancer Institute (NCI)
Cohort
University of Southern California (USC)
Cohort
 
Organizations with Un-Funded Participants:
 
Organization name:
Approx # of participants:
Description of organization's role(s):
American Cancer Society (ACS)
Cohort
Harvard University
Harvard School of Public Health
Cohort
Imperial College London
Cohort
United States Department of Health and Human Services
   National Institutes of Health (NIH)
National Cancer Institute (NCI)
Cohort
University of Southern California (USC)
Cohort
 
TOTAL PARTICIPANTS:
 

Notes on Participants/Organizations:

   
     
 
 

Communications Technology Used :

   
 

Technical Capabilities :

   
  Key Articles :    
 

Project-reported performance data :

  This international consortium was first funded in 2003 and over its first four years assessed 55 candidate genes in the steroid hormone metabolism and IGF pathways in relation to risk for breast and prostate cancer, as well as single nucleotide polymorphisms (SNPs) in 22 additional genes in these and other important pathways that were not listed in the original grant application. In this phase of the research project, resequencing and genotyping data on these candidate genes were obtained, and tag-SNPs were selected in these genes. These data are available to the research community on a public Web site. Genotyping of these SNPs in more than 7,000 cases of breast cancer and more than 8,500 cases of prostate cancer has been completed or is near completion as of mid-2007. The investigators have established databases at two data coordinating centers for breast cancer and prostate cancer. With the accrual of additional cases by mid-2007, they expect that these databases can be expanded to 14,000 cases of breast cancer, and 16,000 cases of prostate cancer.

Starting in 2005, NCI's Cancer Genetic Markers of Susceptibility (CGEMS) initiative, has been conducting genome-wide association studies (GWAS) in two of the BPC3 studies (prostate cancer in the PLCO study, and breast cancer in the NHS) with replication for SNPs highly ranked in the scan in the other studies of the BPC3. An admixture GWAS for prostate cancer was performed in the Multiethnic Cohort and identified an important susceptibility locus at chromosome 8q24. Other GWASs are ongoing, including a breast cancer scan using pooled DNAs in the Women's Health Initiative (WHI), and a breast cancer scan at the University of Cambridge, England. Infrastructure is now needed to rapidly verify findings in large independent data sets, to determine the role of genetic determinants in important clinical subtypes of these diseases, and to identify gene-environment interactions.

Projects developed within the BPC3 are fostering continuing interactions between the genomic and epidemiologic research communities and are integrating the rapid advances in genomic research into large-scale epidemiologic studies.
 
 
         
    
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