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Name of Collaboratory :

 

Carotene and Retinol Efficacy Trial (CARET)

 
 

URL :

  http://www.compass.fhcrc.org/caretWeb/Default.aspx  
 

Collaboratory Status :

 
Completed   Start Date : 1985 End Date : 2005 Info Last Updated : Mon, Nov 1 2010 9:01pm PDT
 
 

Primary Collaboratory Function :

  Community Data Systems  
 

Secondary Collaboratory Functions :

  Distributed Research Center  
 

Domain(s) :

  NON-S&E >Health and Medical Sciences >Public Health, NON-S&E >Health and Medical Sciences >Epidemiology  
 

Brief Description of the Collaboratory :

 

The mission of CARET is to share biological specimens from the CARET Biorepository with researchers of hypothesis-driven studies investigating cancer causation, early detection, and treatment.

The Carotene and Retinol Efficacy Trial (CARET) was a randomized, double-blind, placebo-controlled trial of the cancer prevention efficacy and safety of a daily combination of 30 mg of beta-carotene and 25,000 IU of retinyl palmitate in 18,314 persons at high risk for lung cancer. CARET began in 1985, and the intervention was halted in January 1996, 21 months ahead of schedule, with the twin conclusions for definitive evidence of no benefit and substantial evidence of a harmful effect of the intervention on both lung cancer incidence and total mortality. CARET continued to follow and collect endpoints on their participants through 2005. During the active intervention phase of CARET, serum, plasma, whole blood, and lung tissue specimens were collected on participants. These biospecimens make up the CARET Biorepository.

Leadership is split into two parts:

1. Operational Leadership. This team is responsible for the daily activities associated with maintaining the CARET Biorepository; working closely with investigators in the development of their proposals; reviewing and processing proposals requesting to use the CARET samples and/or data; providing statistical support to investigators utilizing CARET samples; maintaining the CARET website; strategizing on ways to maximize the CARET samples; pulling and shipping CARET samples; and maintaining Institutional Review Board compliance.

2. Scientific Leadership. The CARET Scientific Review Committee comprises the CARET Investigators and CARET Co-Investigators. This committee is charged with reviewing study proposals requesting the use of CARET specimens and/or data.

Cohort Consortium Member. See http://epi.grants.cancer.gov/Consortia/members/caret.html.

 
 

Access to Instruments :

   
 

Access to Information Resources :

  They have established policies for the use of the CARET Biorepository and a process for review and decision making of proposed studies. One of the important premises of these policies is recognition of the unique characteristics of the CARET population and the limited number of specimens available. It has been a policy of the CARET Steering Committee that these specimens should not be used to conduct pilot studies or methods development that can be easily conducted in other populations, but only for analyses that focus on confirming or refuting important relevant hypotheses. Their website provide investigators with background information on CARET, the findings of the trial, specimen availability, and information on how to request specimens for hypothesis-driven studies.  
 

Access to People as Resources :

   
 

Funding Agency or Sponsor :

 
United States Department of Health and Human Services
National Institutes of Health (NIH)
National Cancer Institute (NCI)
Division of Cancer Prevention (NCI) (DCP)
Fred Hutchinson Cancer Research Center
 
 
 

Notes on Funding Agencies/Sponsors:

 
 
 
Organizations with Funded Participants:
 
Organization name:
Approx # of participants:
Description of organization's role(s):
University of Michigan
   UM School of Medicine
      Center for Computational Medicine and Bioinformatics (CCMB)
1
Scientific Leadership
Kaiser Permanete
   Center for Health Research (CHR)
1
Scientific Leadership
University of California, Irvine
   UC Irvine Healthcare
1
Scientific Leadership
   College of Medicine (UCIrvine)
1
Scientific Leadership
Fred Hutchinson Cancer Research Center
3
Operational/Scientific Leadership
United States Department of Health and Human Services
   National Institutes of Health (NIH)
      National Cancer Institute (NCI)
1
Scientific Leadership
University of Washington
   School of Public Health (University of Washington)
1
Scientific Leadership
University of California, San Francisco (UCSF)
   UCSF Medical Center
1
Scientific Leadership
Yale University
   Yale School of Public Health
1
Scientific Leadership
   Yale School of Medicine
2
Scientific Leadership
 
TOTAL PARTICIPANTS:
13
 

Notes on Participants/Organizations:

   
     
 
 

Communications Technology Used :

   
 

Technical Capabilities :

   
  Key Articles :    
 

Project-reported performance data :

   
 
         
    
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