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Name of Collaboratory :


Cellular Approaches for Rare Pulmonary Diseases (CARPuD)


URL :  

Collaboratory Status :

In Development   Start Date : 2008 End Date : Info Last Updated : Mon, Nov 1 2010 9:01pm PDT

Primary Collaboratory Function :

  Distributed Research Center  

Secondary Collaboratory Functions :

  Community Data Systems  

Domain(s) :

  BIOLOGICAL/AGRICULTURAL SCIENCES >Biological Sciences >Biomedical Sciences, BIOLOGICAL/AGRICULTURAL SCIENCES >Biological Sciences >Pathology, Human and Animal  

Brief Description of the Collaboratory :


Goal of the partners of the CARPuD network is the development of innovative therapies for the treatment of the rare lung diseases like AATD, CF, and SD, based on the concept to genetically correct the patient-specific gene defect in autologous iPS cells prior to expansion, differentiation and clinical application.
Aim of the overall project of the present first funding period of the CARPuD consortium is the generation of iPS cells, their differentiation into lung epithelial cells, and application for elucidation of cellular and molecular pathomechanisms. Besides, cell therapeutic approaches are developed and evaluated in appropriate animal models.

Whereas work schedules provided for the first funding period still are predominantly in the field of basic research, projects of a potential second funding period will concentrate on the application of differentiated lung epithelial cells for advanced studies on cellular disease mechanisms and development of improved (stem) cell-based transplantation strategies for the respective lung diseases. In close collaboration with the future German Lung Center (coordination: T. Welte, Hannover Medical School) a patients’ fibroblast bank is planned to be established to enable the generation and evaluation of a variety of patient-specific stem cells. These joint activities finally may provide the basis for first pre-clinical large animal experiments and clinical phase-1 studies with the perspective to be transferred to general clinical practice in the future.


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Funding Agency or Sponsor :

Federal Ministry of Education and Research (BMBF)

Notes on Funding Agencies/Sponsors:
Funding period is 2008-2012.

Organizations with Funded Participants:
Organization name:
Approx # of participants:
Description of organization's role(s):
Hannover Medical School
Consortium member; coordinates project
Max Planck Society
   Max Planck Institute for Molecular Biomedicine
Consortium member
Ruprecht-Karls-Universität Heidelberg
Consortium member
Saarland University
Consortium member

Notes on Participants/Organizations:


Communications Technology Used :


Technical Capabilities :

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